Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level
نویسندگان
چکیده
منابع مشابه
Acute Phase Reactants as a Prognostic Factor in Acute Stroke
Introduction: Elevated levels of CRP are present among patients at risk for further first-ever myocardial infarction and stroke. It has been shown that after ischemic stroke, increased levels of CRP are associated with unfavorable outcomes. Methods: From 120 patients admitted to the emergency unit of our hospital with the diagnosis of stroke CRP, D-dimer and ferritin level was measured and the ...
متن کاملInterleukin-6 and the acute phase response.
systemic reaction characterized by fever, leukocytosis, increase in erythrocyte sedimentation rate, increases in Leucocytosis secretion of ACTH and glucocorticoids, activation of Complement activat complement and clotting cascades, decreases in serum levels of iron and zinc, a negative nitrogen balance, and by dramatic changes in the concentration of some plasma ,l' proteins. These proteins are...
متن کاملActivation of the STAT3/acute phase response factor transcription factor by interleukin-5.
The receptor for interleukin-5 (IL-5R) is composed of a unique alpha chain (IL-5R alpha) expressed on eosinophils and basophils, associated with a beta c subunit, which is shared by the receptors for IL-3 and granulocyte macrophage-colony stimulating factor. One of the molecular events activated via the IL-5R is the JAK/STAT signaling pathway. Recent reports have shown that IL-5 induces tyrosin...
متن کاملacute phase reactants as a prognostic factor in acute stroke
introduction: elevated levels of crp are present among patients at risk for further first-ever myocardial infarction and stroke. it has been shown that after ischemic stroke, increased levels of crp are associated with unfavorable outcomes. methods: from 120 patients admitted to the emergency unit of our hospital with the diagnosis of stroke crp, d-dimer and ferritin level was measured and the ...
متن کاملCiliary neurotrophic factor: pharmacokinetics and acute-phase response in rat.
Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circul...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1993
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.13.1.276-288.1993